Ajax Startled Real Madrid at the Bernabeu and Knocked them out of the Champions League.

Real Madrid's dismal run of form continued as Ajax won 4-1 at the Santiago Bernabeu to dump the Champions League holders out of the competition for the first time since 2014-15.

After winning Europe's elite club tournament in three consecutive years under Zinedine Zidane, a tough first campaign since the French icon's departure was capped in remarkable fashion on Tuesday in a 5-3 aggregate loss.

Madrid fell apart in the first half and saw their 2-1 first-leg lead overturned in the opening 20 minutes by goals from Hakim Ziyech and David Neres as Ajax ran riot.

The irrepressible Dusan Tadic added another with a controversial second-half strike, leaving Madrid requiring three goals to stay in the competition, and although Marco Asensio got one back, a fourth home defeat in a row never looked in doubt as Lasse Schone made it four.